RNA PROCESSING ERRORS TRIGGERED BY CADMIUM AND INTEGRATOR COMPLEX DISRUPTION ARE SIGNALS FOR ENVIRONMENTAL STRESS

RNA processing errors triggered by cadmium and integrator complex disruption are signals for environmental stress

Abstract Background Adaptive responses to stress are essential for cell and organismal survival.In metazoans, little is known about the impact of environmental stress on RNA homeostasis.Results By studying the regulation of a cadmium-induced gene named numr-1 in Caenorhabditis elegans, we discovered that disruption of RNA processing acts as a signa

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Black Humor on the Film Screen: From Folk to Popular Culture

The paper is dealing with the complex phenomenon of read more black humor.Starting from different definitions about its origin, the author questions its folklore origin in Greek antiquity.Through the prism of the theories of Olga Freidneberg and Michael Bakhtin, parody and/or carneval appear as a worldview contrary and at the same time parallel to

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Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological health [version 2; peer review: 2 approved]

The circadian clock is a fundamental biological mechanism that orchestrates essential cellular and physiological processes to optimize fitness and health.The basic functional unit is the cell-autonomous oscillator, consisting of intersecting negative feedback loops.Whereas the core loop is primarily responsible for rhythm generation, auxiliary loop

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